drugset / Trial / NCT06205706

BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid Tumors

NCT06205706 ↗

Phase 1/2 Active not recruiting 35 enrolled BioInvent International AB Merck Sharp & Dohme LLC · collab
Non-randomizedSequentialOpen-labelTreatment

Summary

The goal of this first in human clinical trial is to test BI-1910 administered as single agent and in combination with pembrolizumab in subjects with advanced/metastatic solid tumors whose disease has progressed after standard therapy. The main questions it aims to answer are: * how safe and tolerable is BI-1910 * what is maximum tolerated or administrated dose * to determine recommended dose for further clinical trials Participants will receive infusions of BI-1910 alone or combination with pembrolizumab every 3 weeks.

Timeline

Start
2023-12-04
Primary completion
2027-07-14
Completion
2028-11-07

Drugs

EvaluationDrugModalityDoseRoute
Subject BI-1910 Monoclonal antibody — Intravenous
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous