drugset / Trial / NCT06221553
Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
Phase 1
Recruiting
9 enrolled
Chulalongkorn University
King Chulalongkorn Memorial Hospital · collab
NaSingle-groupOpen-labelTreatment
Summary
A Phase 1 clinical trial to evaluate the safety and early efficacy of CAR T-cell with IL-7Ra signal targeting B7H3 in children with diffuse intrinsic pontine glioma (DIPG) patients after complete standard treatments.
Timeline
- Start
- 2024-03-01
- Primary completion
- 2026-03-01
- Completion
- 2026-09-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | B7H3 specific CAR T cell with IL-7Ra signaling domain | Cell therapy | 1e+07 cells | Other |
| Subject | B7H3 specific CAR T cell with IL-7Ra signaling domain | Cell therapy | 3e+07 cells | Other |
| Subject | B7H3 specific CAR T cell with IL-7Ra signaling domain | Cell therapy | 1e+08 cells | Other |