Paroxetine Safety and Efficacy in Rheumatoid Arthritis

Summary

Rheumatoid arthritis (RA) is a systemic chronic auto-inflammatory disorder which imposes a remarkable burden of morbidity and mortality on global health. The complex interaction between genetics, environment, and immunological response contribute to RA pathogenesis. Current treatment comprises conventional disease-modifying anti-rheumatic drugs (DMARDs) followed by biological DMARDs, if necessary, to achieve low disease activity or remission. Therapeutics used in RA had limitations in tolerability, access, and response duration and magnitude. Consequently, implementation of safe adjunctive treatment for RA is urgently needed to boost the therapeutic response.

Timeline

Start

2024-01-31

Primary completion

2025-07-20

Completion

2025-07-20

Publications

• Aldossary KM, Abdallah MS, Mosalam EM, Kamal N, Saif DS, Elsayed SA, Afifi N, Zakaraia HG, Khrieba MO, Bahaa MM. Efficacy of Paroxetine as an Adjuvant Therapy in Rheumatoid Arthritis Patients: A Randomized Controlled Study. Drug Des Devel Ther. 2025 Dec 30;19:11925-11939. doi: 10.2147/DDDT.S572677. eCollection 2025.

Drugs

Indications