drugset / Trial / NCT06233799
Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The primary objective of this study is to evaluate the efficacy of extended release naltrexone plus bupropion XL (XR-NTX/BUP-XL) compared to matched injectable and oral placebo (iPLB/oPLB) in reducing methamphetamine (MA) use in individuals with moderate or severe methamphetamine use disorder (MUD) seeking to stop or reduce MA use.
Timeline
- Start
- 2024-07-01
- Primary completion
- 2026-10-30
- Completion
- 2027-04-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupropion | Small molecule | 450 mg | Oral |
| Subject | Naltrexone | Small molecule | — | Other |