drugset / Trial / NCT06245291

Study of Imdusiran (AB-729) in Combination With Intermittent Dosing of Durvalumab in Subjects With Chronic HBV Infection

NCT06245291 ↗

Phase 2 Withdrawn Arbutus Biopharma Corporation
RandomizedParallel-groupOpen-labelTreatment

Summary

This is a phase 2a, open-label, multicenter study investigating the safety, tolerability, and antiviral activity of durvalumab administered at targeted times during a 48-week treatment period of imdusiran in virologically-suppressed CHB subjects

Timeline

Start
2024-05-01
Primary completion
2024-08-01
Completion
2024-08-01

Outcome

Outcome not reported

Stopped (Business): “Sponsor Decision”

Drugs

EvaluationDrugModalityDoseRoute
Subject Durvalumab Monoclonal antibody — Intravenous
Subject Imdusiran Small interfering RNA (siRNA) 60 mg Subcutaneous