Optimal Treatment of Acute Skeletal Muscle Injury

Not yet recruiting 20 enrolled Bispebjerg Hospital

RandomizedParallel-groupTriple-blindBasic science

Summary

Acute muscle strain injuries occur both during sports, in leisure time activities and during manual occupation and represent a major clinical challenge and has societal economic costs. The recovery time is long and a substantial injury recurrence is observed. Despite current best evidence rehabilitation with early mechanical loading, a significant loss of muscle mass, fatty infiltration and formation of scar tissue is reported. Animal models and human in vitro experiments suggest that inflammation is vital in the early period after an injury, however an inhibition of inflammatory processes is beneficial for healing. We investigate here whether a pharmacological inhibition of inflammatory pathways in the 2nd week following a muscle strain injury will provide a better clinical outcome and an advantageous cellular profile than rehabilitative training alone would.

Timeline

Start: 2024-02-15
Primary completion: 2025-07-31
Completion: 2029-12-31

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Naproxen	Small molecule	500 mg	—

Indications

No indication recorded.