The Effects of High-dose Dual Therapy With Probiotics on Gut Microbiota for Helicobacter Pylori Rescue Treatment

Completed 72 enrolled Zhongshan Hospital (Xiamen), Fudan University

RandomizedParallel-groupOpen-labelTreatment

Summary

The aim of this study was to evaluate the effects of High-dose Dual therapy combined with probiotics on the gut microbiota for Helicobacter pylori rescue treatment.

Timeline

Start: 2024-01-31
Primary completion: 2024-12-30
Completion: 2025-02-28

Publications

Results Hu Y, Xu X, Ouyang YB, He C, Li NS, Xie C, Peng C, Zhu ZH, Shu X, Xie Y, Lu NH, Zhu Y. Altered Gut Microbiota and Short-Chain Fatty Acids After Vonoprazan-Amoxicillin Dual Therapy for Helicobacter pylori Eradication. Front Cell Infect Microbiol. 2022 Jun 2;12:881968. doi: 10.3389/fcimb.2022.881968. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bacillus subtilis enteric-coated capsules	Unknown	—	—
Background	Amoxicillin	Other / unclassified	0.75 g	—
Background	Vonoprazan	Other / unclassified	20 mg	—

The Effects of High-dose Dual Therapy With Probiotics on Gut Microbiota for Helicobacter Pylori Rescue Treatment

Summary

Timeline

Publications

Drugs

Indications