drugset / Trial / NCT06333678

A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)

NCT06333678

RandomizedParallel-groupOpen-labelTreatment

Summary

In this study, the researchers will look at whether having participants switch from durvalumab to sotorasib when they have detectable minimal residual disease (MRD) is an effective treatment approach for locally advanced non-small cell lung cancer (LA-NSCLC). The researchers will see whether this switch to sotorasib can control LANSCLC longer compared to the treatment approach of staying on durvalumab (and not switching to sotorasib).

Timeline

Start
2024-03-20
Primary completion
2026-01-27
Completion
2026-01-27

Drugs

EvaluationDrugModalityDoseRoute
Comparator Durvalumab Monoclonal antibody 10 mg/kg Intravenous
Comparator Durvalumab Monoclonal antibody 1500 mg/kg Intravenous
Subject Sotorasib Small molecule 960 mg