drugset / Trial / NCT06336291
A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence
RandomizedParallel-groupOpen-labelTreatment
Summary
The trial aims to collect safety, efficacy, exposure, dose- response, pharmacokinetic and pharmacodynamic information of the combination of L19TNF and lomustine at different dose levels in patients with Glioblastoma at progression or recurrence
Timeline
- Start
- 2024-05-22
- Primary completion
- 2026-06
- Completion
- 2026-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lomustine | Small molecule | 90 mg/m2 | — |
| Subject | Lomustine | Small molecule | 110 mg/m2 | — |
| Subject | Onfekafusp alfa | Protein / enzyme biologic | 7 ug/kg | Other |
| Subject | Onfekafusp alfa | Protein / enzyme biologic | 10 ug/kg | Other |
| Subject | Onfekafusp alfa | Protein / enzyme biologic | 13 ug/kg | Other |