drugset / Trial / NCT06347133

Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia

NCT06347133 ↗

Phase 3 Active not recruiting 1456 enrolled Arrowhead Pharmaceuticals
RandomizedParallel-groupQuadruple-blindTreatment

Summary

This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with hypertriglyceridemia (HTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo and be evaluated for efficacy and safety.

Timeline

Start
2024-05-21
Primary completion
2026-06-01
Completion
2026-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Plozasiran Small interfering RNA (siRNA) — Subcutaneous

Indications