Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS

Phase 1 Unknown 60 enrolled Ain Shams University

RandomizedParallel-groupSingle-blindTreatment

Summary

An Exploratory Randomized double-arm controlled trial to evaluate the immunomodulatory effect of low versus high dose of Alveofact with or without Budesonide.

Timeline

Start: 2022-08-18
Primary completion: 2024-07
Completion: 2024-10

Publications

Rashad AM, El-Khazragy N, Awad H, Gad GI, Rabie D. Dose-dependent effects of Alveofact with and without steroids on neutrophil extracellular traps in neonatal respiratory distress syndrome. Pediatr Res. 2026 Mar 23. doi: 10.1038/s41390-026-04824-9. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	AeroFact	Unknown	50 mg/kg	Other
Subject	AeroFact	Unknown	100 mg/kg	Other
Subject	Budesonide	Small molecule	0.25 mg/kg	—

Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS

Summary

Timeline

Publications

Drugs

Indications