drugset / Trial / NCT06385600

Intravenous Labetalol vs Phentolamine for the Management of Severe Preeclampsia.

NCT06385600

Unknown 200 enrolled Assiut University
RandomizedParallel-groupDouble-blindTreatment

Summary

The only effective treatment of severe preeclampsia is delivery of the fetus but immediate antihypertensive treatment is given to stabilize the patient and prevent further complications. All antihypertensive medication can potentially cross the placenta. At this time, there are no randomized control trials to base a recommendation for the use of one antihypertensive agent over another. However, certain medications are effective in lowering blood pressure with an acceptable safety profile in pregnancy. The choice of therapy depends on the acuity and severity of hypertension

Timeline

Start
2024-05-20
Primary completion
2026-01-20
Completion
2026-03-20

Drugs

EvaluationDrugModalityDoseRoute
Comparator Labetalol Small molecule Intravenous
Comparator Phentolamine Small molecule 1 ug/kg Intravenous

Indications