drugset / Trial / NCT06385600
Intravenous Labetalol vs Phentolamine for the Management of Severe Preeclampsia.
RandomizedParallel-groupDouble-blindTreatment
Summary
The only effective treatment of severe preeclampsia is delivery of the fetus but immediate antihypertensive treatment is given to stabilize the patient and prevent further complications. All antihypertensive medication can potentially cross the placenta. At this time, there are no randomized control trials to base a recommendation for the use of one antihypertensive agent over another. However, certain medications are effective in lowering blood pressure with an acceptable safety profile in pregnancy. The choice of therapy depends on the acuity and severity of hypertension
Timeline
- Start
- 2024-05-20
- Primary completion
- 2026-01-20
- Completion
- 2026-03-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Labetalol | Small molecule | — | Intravenous |
| Comparator | Phentolamine | Small molecule | 1 ug/kg | Intravenous |