drugset / Trial / NCT06387082

A Clinical Study of HMPL-506 in Patients With Hematological Malignancies

NCT06387082 ↗

Phase 1 Recruiting 132 enrolled Hutchmed
Non-randomizedSequentialOpen-labelTreatment

Summary

This is a Phase 1, multicenter, open-label clinical study of HMPL-506 administered orally in the treatment of hematological malignancies. Only eligible patients who provide the signed informed consent form (ICF) can be enrolled in this study. The study consists of two phases, i.e., a dose escalation phase and a dose expansion phase. The study is expected to enroll approximately 60 to 132 patients, including approximately 30 to 38 patients in the dose escalation phase and approximately 30 to 72 patients in the dose expansion phase.

Timeline

Start
2024-05-27
Primary completion
2027-10-08
Completion
2027-12-08

Drugs

EvaluationDrugModalityDoseRoute
Subject HMPL-506 Unknown 25 mg Oral
Subject HMPL-506 Unknown 50 mg Oral
Subject HMPL-506 Unknown 75 mg Oral
Subject HMPL-506 Unknown 100 mg Oral
Subject HMPL-506 Unknown 150 mg Oral
Subject HMPL-506 Unknown 200 mg Oral
Subject HMPL-506 Unknown 300 mg Oral
Subject HMPL-506 Unknown 400 mg Oral