Radiation Dosimetry of the 18 kDa Translocator Protein Ligand [18F]PBR111 in Humans

Summary

The 18 kDa translocator protein (TSPO) is a mitochondrial protein that becomes overexpressed during neuroinflammatory conditions, such as in Alzheimer's disease or multiple sclerosis. TSPO is of interest because it serves as a marker for microglial and astrocytic activity, measurable via in vivo positron emission tomography (PET) molecular imaging. \[18F\]PBR111 is a second-generation TSPO PET radioligand with high signal specificity but a sensitivity to TSPO polymorphism, in comparison with first-generation ligands. This study focused on the biodistribution and dosimetry of \[18F\]PBR111 in healthy humans.

Timeline

Start

2024-06-24

Primary completion

2024-07-30

Completion

2024-07-30

Publications

• Results Tournier BB, Mansouri Z, Salimi Y, Ceyzeriat K, Mathoux G, Richard-Lepouriel H, Zullino D, Bois F, Zaidi H, Garibotto V, Tsartsalis S, Millet P. Radiation dosimetry of the 18 kDa translocator protein ligand [18F]PBR111 in humans. Nucl Med Biol. 2025 May-Jun;144-145:109011. doi: 10.1016/j.nucmedbio.2025.109011. Epub 2025 Mar 29.

Drugs

Indications

No indication recorded.