Clinical and Laboratory Evaluation of Antifungal Resistance in Tinea Capitis

Summary

AIM OF WORK : 1. Detect the most common fungal strains that cause tinea capitis 2. Detect Different effectiveness of terbinafine in different cases 3. Detect the resistant strains. 4. Detect the mycological and the clinical cure rates upon using systemic terbinafine in treatment of tinea capitis

Timeline

Start

2024-05

Primary completion

2025-04

Completion

2025-05

Publications

• Background Appelt L, Nenoff P, Uhrlass S, Kruger C, Kuhn P, Eichhorn K, Buder S, Beissert S, Abraham S, Aschoff R, Bauer A. [Terbinafine-resistant dermatophytoses and onychomycosis due to Trichophyton rubrum]. Hautarzt. 2021 Oct;72(10):868-877. doi: 10.1007/s00105-021-04879-1. Epub 2021 Aug 30. German.
• Background Hawks MK, Rupert JP, Svarverud JE. Terbinafine for Onychomycosis. Am Fam Physician. 2018 Aug 1;98(3):Online. No abstract available.
• Background Lian LD, Shi LY, Zhu J, Liu R, Shi L, Ren A, Yu HS, Zhao MW. GlSwi6 Positively Regulates Cellulase and Xylanase Activities through Intracellular Ca2+ Signaling in Ganoderma lucidum. J Fungi (Basel). 2022 Feb 14;8(2):187. doi: 10.3390/jof8020187.
• Results Moreno-Sabater A, Normand AC, Bidaud AL, Cremer G, Foulet F, Brun S, Bonnal C, Ait-Ammar N, Jabet A, Ayachi A, Piarroux R, Botterel F, Houze S, Desoubeaux G, Hennequin C, Dannaoui E. Terbinafine Resistance in Dermatophytes: A French Multicenter Prospective Study. J Fungi (Basel). 2022 Feb 23;8(3):220. doi: 10.3390/jof8030220.

Drugs

Indications