FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage

Summary

A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage. The study aim is to determine if early administration of enteral fludrocortisone in aneurysmal subarachnoid haemorrhage reduce death and dependency at six months.

Timeline

Start

2025-08-13

Primary completion

2029-07-31

Completion

2030-07-31

Publications

• Cohen J, Delaney A, Udy A, Andersen C, Anderson CS, Bellapart J, Burrell LM, Devaux A, Evans DM, Fitzgerald E, Garside T, Hammond N, Hardie M, Jeffree RL, Knowles S, Lassig-Smith M, Li Q, Nethathe G, Rajbhandari D, Ramanan M, Talbot P, Taylor C, Wright J, Young MJ, Young PJ, Venkatesh B. Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial. Crit Care Resusc. 2025 Jun 30;27(2):100116. doi: 10.1016/j.ccrj.2025.100116. eCollection 2025 Jun.

Drugs

Indications