Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model

Phase 4 Unknown 24 enrolled Universidad del Desarrollo Technical University of Munich · collab

NaSingle-groupOpen-labelDiagnostic

Summary

in healthy patients undergoing elective surgery, after a very slow induction, using Eleveld's kinetics as a reference, after loss of consciousness (LOC) and intubation, proceed to infuse propofol until 1% burst suppression ratio is obtained. Then return to the LOC concentration. The BISindex predicted by the model and the real one will be evaluated. The evolution of spectral density frequencies over time will also be evaluated.

Timeline

Start: 2013-09-01
Primary completion: 2023-09-15
Completion: 2024-09-15

Publications

Background Sepulveda PO, Mora X. [Reevaluation of the time course of the effect of propofol described with the Schnider pharmacokinetic model]. Rev Esp Anestesiol Reanim. 2012 Dec;59(10):542-8. doi: 10.1016/j.redar.2012.07.019. Epub 2012 Oct 4. Spanish.
Results Eleveld DJ, Colin P, Absalom AR, Struys MMRF. Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation. Br J Anaesth. 2018 May;120(5):942-959. doi: 10.1016/j.bja.2018.01.018. Epub 2018 Mar 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	15 mg/kg	—

Indications

No indication recorded.