drugset / Trial / NCT06428188

Sequential CAR-T Cells Targeting BCMA/CD19 in Patients With Relapsed/ Refractory Autoimmune Diseases

NCT06428188 ↗

Phase 1/2 Recruiting 60 enrolled Essen Biotech
NaSingle-groupOpen-labelTreatment

Summary

This is an open, single-arm, clinical study to evaluate the efficacy and safety of chimeric antigen receptor T cell immunotherapy (CAR-T) targeting BCMA or CD19 or both sequentially in the treatment of Relapsed/ Refractory Autoimmune Disease such as Sjogren's Syndrome or Systemic Lupus Erythematosus and other Autoimmune Disease.

Timeline

Start
2024-05-29
Primary completion
2025-12-10
Completion
2026-12-28

Drugs

EvaluationDrugModalityDoseRoute
Subject BCMA/CD19 Chimeric Antigen Receptor T (CAR T) cells Cell therapy — Intravenous