Cannabidiol After Multi-Trauma for Pain and Opioid Therapy

Summary

The aim of this project is to investigate the therapeutic potential and safety of acute Cannabidiol (CBD) treatment on longitudinal pain symptoms, and to assess potential interactions with pain mediators including opioids and sex on CBD treatment response. To this end, this research protocol proposes a comprehensive translational approach including a placebo-controlled randomized clinical trial comparing two daily doses of CBD treatment administered for one month on pain relief. This study will also compare intervention conditions on inflammation markers, participant quality of life, sleep quality, depression, anxiety, cognition and orthopaedic function.

Timeline

Start

2025-06-01

Primary completion

2027-06

Completion

2027-06

Publications

• Brazeau D, Deshaies AA, Williamson D, Bernard F, Arbour C, Pinard AM, Rouleau D, De Beaumont L. Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomised, placebo-controlled, clinical trial protocol. BMJ Open. 2025 Feb 20;15(2):e092919. doi: 10.1136/bmjopen-2024-092919.

Drugs

Indications

No indication recorded.