drugset / Trial / NCT06452134
Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction
Phase 4
Unknown
70 enrolled
Zahra Nejati
Babak Ghadirzadeh, medical student, Kurdistan university of medical sciences · collabHady Mohammadi, Director of oral and maxillofacial surgery department, school of dentistry, Kurdistan university of medical sciences · collabKurdistan University of Medical Sciences · collabYousef Moradi, Assistant professor, Department of epidemiology and biostatistics, Kurdistan university of medical sciences · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The goal of this clinical trial is to asses the effect of Coenzyme Q10 administration in patients from any gender group who are older than 18 years old undergoing wisdom tooth extraction. The main questions it aims to answer are: does Coenzyme Q10 help with better tissue healing? does Coenzyme Q10 administration lower the prevalence of Dry socket after surgery? does Coenzyme Q10 prevent TMD (Temporomandibular disorders) while recovering from surgery? how does Coenzyme Q10 administration effect the answers to SF-36 health survey in patients? Researchers will compare Coenzyme Q10 to a placebo (a look-alike substance that contains no drug) to see if it has any effect on mentioned parameters. Participants will: * take coenzyme Q10 (100mg) daily for 30 days after surgery. * will be examined and evaluated 1, 7, 14 and 30 days after completion of surgery.
Timeline
- Start
- 2024-07
- Primary completion
- 2024-09
- Completion
- 2025-05
Publications
- Results Rafetto LK. Managing Impacted Third Molars. Oral Maxillofac Surg Clin North Am. 2015 Aug;27(3):363-71. doi: 10.1016/j.coms.2015.04.004. Epub 2015 Jun 9.
- Results Glickman A, Karlis V. Pediatric Benign Soft Tissue Oral and Maxillofacial Pathology. Oral Maxillofac Surg Clin North Am. 2016 Feb;28(1):1-10. doi: 10.1016/j.coms.2015.07.005.
- Results Kaner KH. Referral and Management Considerations for a Biopsy: Why Choose the Oral and Maxillofacial Surgeon. Dent Clin North Am. 2020 Jan;64(1):241-247. doi: 10.1016/j.cden.2019.08.013. Epub 2019 Oct 21.
- Results Kiencalo A, Jamka-Kasprzyk M, Panas M, Wyszynska-Pawelec G. Analysis of complications after the removal of 339 third molars. Dent Med Probl. 2021 Jan-Mar;58(1):75-80. doi: 10.17219/dmp/127028.
- Results Hallab L, Azzouzi A, Chami B. Quality of life after extraction of mandibular wisdom teeth: A systematic review. Ann Med Surg (Lond). 2022 Aug 21;81:104387. doi: 10.1016/j.amsu.2022.104387. eCollection 2022 Sep.
- Results Hao M, Duan M, Yang Z, Zhou H, Li S, Xiang J, Wu H, Liu H, Chang L, Wang D, Liu W. Engineered stem cell exosomes for oral and maxillofacial wound healing. Front Bioeng Biotechnol. 2022 Oct 24;10:1038261. doi: 10.3389/fbioe.2022.1038261. eCollection 2022.
- Results Cluis CP, Burja AM, Martin VJ. Current prospects for the production of coenzyme Q10 in microbes. Trends Biotechnol. 2007 Nov;25(11):514-21. doi: 10.1016/j.tibtech.2007.08.008.
- Results Moon HJ, Ko WK, Han SW, Kim DS, Hwang YS, Park HK, Kwon IK. Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. Biochem Biophys Res Commun. 2012 Feb 10;418(2):247-53. doi: 10.1016/j.bbrc.2012.01.005. Epub 2012 Jan 9.
- Results Sifuentes-Franco S, Sanchez-Macias DC, Carrillo-Ibarra S, Rivera-Valdes JJ, Zuniga LY, Sanchez-Lopez VA. Antioxidant and Anti-Inflammatory Effects of Coenzyme Q10 Supplementation on Infectious Diseases. Healthcare (Basel). 2022 Mar 7;10(3):487. doi: 10.3390/healthcare10030487.
- Results Li X, Zhan J, Hou Y, Hou Y, Chen S, Luo D, Luan J, Wang L, Lin D. Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H2O2 Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury. Oxid Med Cell Longev. 2019 Dec 12;2019:6493081. doi: 10.1155/2019/6493081. eCollection 2019.
- Results Hargreaves I, Heaton RA, Mantle D. Disorders of Human Coenzyme Q10 Metabolism: An Overview. Int J Mol Sci. 2020 Sep 13;21(18):6695. doi: 10.3390/ijms21186695.
- Results Moon HJ, Ko WK, Jung MS, Kim JH, Lee WJ, Park KS, Heo JK, Bang JB, Kwon IK. Coenzyme q10 regulates osteoclast and osteoblast differentiation. J Food Sci. 2013 May;78(5):H785-891. doi: 10.1111/1750-3841.12116. Epub 2013 Apr 12.
- Results Kaushik AS, Strath LJ, Sorge RE. Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation. Pain Ther. 2020 Dec;9(2):487-498. doi: 10.1007/s40122-020-00200-5. Epub 2020 Oct 21.
- Results Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician. 2005 Sep 15;72(6):1065-70.
- Results Choi BS, Song HS, Kim HR, Park TW, Kim TD, Cho BJ, Kim CJ, Sim SS. Effect of coenzyme Q10 on cutaneous healing in skin-incised mice. Arch Pharm Res. 2009 Jun;32(6):907-13. doi: 10.1007/s12272-009-1613-3. Epub 2009 Jun 26.
- Results Mencucci R, Favuzza E, Boccalini C, Lapucci A, Felici R, Resta F, Chiarugi A, Cavone L. CoQ10-containing eye drops prevent UVB-induced cornea cell damage and increase cornea wound healing by preserving mitochondrial function. Invest Ophthalmol Vis Sci. 2014 Oct 9;55(11):7266-71. doi: 10.1167/iovs.14-15306.
- Results Gulsen I, Ak H, Colcimen N, Alp HH, Akyol ME, Demir I, Atalay T, Balahroglu R, Ragbetli MC. Neuroprotective Effects of Thymoquinone on the Hippocampus in a Rat Model of Traumatic Brain Injury. World Neurosurg. 2016 Feb;86:243-9. doi: 10.1016/j.wneu.2015.09.052. Epub 2015 Sep 30.
- Results Manzar H, Abdulhussein D, Yap TE, Cordeiro MF. Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain. Int J Mol Sci. 2020 Dec 6;21(23):9299. doi: 10.3390/ijms21239299.
- Results Al Saadi T, Assaf Y, Farwati M, Turkmani K, Al-Mouakeh A, Shebli B, Khoja M, Essali A, Madmani ME. Coenzyme Q10 for heart failure. Cochrane Database Syst Rev. 2021 Feb 3;(2)(2):CD008684. doi: 10.1002/14651858.CD008684.pub3.
- Results Abdelkader HA, Rashed LA, Assaad E, Saleh MA. Serum and tissue levels of coenzyme Q10 in pemphigus vulgaris. J Cosmet Dermatol. 2022 Jul;21(7):3002-3006. doi: 10.1111/jocd.14511. Epub 2021 Oct 3.
- Results Ghasemi S, Torab Z, Shirmohammadi A, Babaloo A, Johari R, Farhadi F, Mobasseri M, Mohammadi H. Evaluation of the effect of coenzyme Q10 supplementation along with scaling and root planing (SRP) on periodontal and gingival indices in controlled diabetic patients. J Adv Periodontol Implant Dent. 2022 Mar 13;14(1):32-37. doi: 10.34172/japid.2022.003. eCollection 2022.
- Results Ko KI, Sculean A, Graves DT. Diabetic wound healing in soft and hard oral tissues. Transl Res. 2021 Oct;236:72-86. doi: 10.1016/j.trsl.2021.05.001. Epub 2021 May 13.
- Results Marini L, Rojas MA, Sahrmann P, Aghazada R, Pilloni A. Early Wound Healing Score: a system to evaluate the early healing of periodontal soft tissue wounds. J Periodontal Implant Sci. 2018 Oct 24;48(5):274-283. doi: 10.5051/jpis.2018.48.5.274. eCollection 2018 Oct.
- Results List T, Jensen RH. Temporomandibular disorders: Old ideas and new concepts. Cephalalgia. 2017 Jun;37(7):692-704. doi: 10.1177/0333102416686302. Epub 2017 Jan 9.
- Results Bowe DC, Rogers S, Stassen LF. The management of dry socket/alveolar osteitis. J Ir Dent Assoc. 2011 Dec-2012 Jan;57(6):305-10.
- Results Reale C, Invernizzi F, Panteghini C, Garavaglia B. Genetics, sex, and gender. J Neurosci Res. 2023 May;101(5):553-562. doi: 10.1002/jnr.24945. Epub 2021 Sep 9.
- Results Newland JA. How do you define age? Nurse Pract. 2014 Jul 13;39(7):6. doi: 10.1097/01.NPR.0000450740.92453.2b. No abstract available.
- Results Bailey E, Kashbour W, Shah N, Worthington HV, Renton TF, Coulthard P. Surgical techniques for the removal of mandibular wisdom teeth. Cochrane Database Syst Rev. 2020 Jul 26;7(7):CD004345. doi: 10.1002/14651858.CD004345.pub3.
- Results Miloro M, DaBell J. Radiographic proximity of the mandibular third molar to the inferior alveolar canal. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Nov;100(5):545-9. doi: 10.1016/j.tripleo.2005.03.009.
- Results Fry RR, Patidar DC, Goyal S, Malhotra A. Proximity of maxillary posterior teeth roots to maxillary sinus and adjacent structures using Denta scan(R). Indian J Dent. 2016 Sep;7(3):126-130. doi: 10.4103/0975-962X.189339.
- Results Dodson TB, Susarla SM. Impacted wisdom teeth. BMJ Clin Evid. 2014 Aug 29;2014:1302.
- Results Unwerawattana W. Common symptoms and type of impacted molar tooth in King Chulalongkorn Memorial Hospital. J Med Assoc Thai. 2006 Sep;89 Suppl 3:S134-9.
- Results Doty RL. Systemic diseases and disorders. Handb Clin Neurol. 2019;164:361-387. doi: 10.1016/B978-0-444-63855-7.00021-6.
- Results Dean E. Anxiety. Nurs Stand. 2016 Jul 13;30(46):15. doi: 10.7748/ns.30.46.15.s17.
- Results Al-Qudah AA, Bani Younis HAB, Awawdeh LA, Daud A. Root and canal morphology of third molar teeth. Sci Rep. 2023 Apr 27;13(1):6901. doi: 10.1038/s41598-023-34134-7.
- Results Mehrotra N, Singh S. Periodontitis. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK541126/
- Results Dolens Eda S, Nakai FV, Santos Parizi JL, Alborghetti Nai G. Cytopathology: a useful technique for diagnosing oral lesions?: a systematic literature review. Diagn Cytopathol. 2013 Jun;41(6):505-14. doi: 10.1002/dc.22875. Epub 2012 May 30.
- Results Yaseen SM, Naik S, Uloopi KS. Ectopic eruption - A review and case report. Contemp Clin Dent. 2011 Jan;2(1):3-7. doi: 10.4103/0976-237X.79289.
- Results Esian D, Bica CI, Stoica OE, Dako T, Vlasa A, Bud ES, Salcudean D, Beresescu L. Prevalence and Manifestations of Dental Ankylosis in Primary Molars Using Panoramic X-rays: A Cross-Sectional Study. Children (Basel). 2022 Aug 8;9(8):1188. doi: 10.3390/children9081188.
- Results van Lummel RC, Walgaard S, Pijnappels M, Elders PJ, Garcia-Aymerich J, van Dieen JH, Beek PJ. Physical Performance and Physical Activity in Older Adults: Associated but Separate Domains of Physical Function in Old Age. PLoS One. 2015 Dec 2;10(12):e0144048. doi: 10.1371/journal.pone.0144048. eCollection 2015.
- Results Montazeri A, Goshtasebi A, Vahdaninia M, Gandek B. The Short Form Health Survey (SF-36): translation and validation study of the Iranian version. Qual Life Res. 2005 Apr;14(3):875-82. doi: 10.1007/s11136-004-1014-5.
- Results Masciocchi E, Maltais M, El Haddad K, Virecoulon Giudici K, Rolland Y, Vellas B, de Souto Barreto P. Defining Vitality Using Physical and Mental Well-Being Measures in Nursing Homes: A Prospective Study. J Nutr Health Aging. 2020;24(1):37-42. doi: 10.1007/s12603-019-1285-8.
- Results Cohen M, Quintner J, van Rysewyk S. Reconsidering the International Association for the Study of Pain definition of pain. Pain Rep. 2018 Mar 5;3(2):e634. doi: 10.1097/PR9.0000000000000634. eCollection 2018 Mar.
- Results Brussow H. What is health? Microb Biotechnol. 2013 Jul;6(4):341-8. doi: 10.1111/1751-7915.12063. Epub 2013 May 6.
- Results Riley RD, Ensor J, Snell KIE, Harrell FE Jr, Martin GP, Reitsma JB, Moons KGM, Collins G, van Smeden M. Calculating the sample size required for developing a clinical prediction model. BMJ. 2020 Mar 18;368:m441. doi: 10.1136/bmj.m441. No abstract available.
- Results Zhong B. How to calculate sample size in randomized controlled trial? J Thorac Dis. 2009 Dec;1(1):51-4.
- Results Althunian TA, de Boer A, Groenwold RHH, Klungel OH. Defining the noninferiority margin and analysing noninferiority: An overview. Br J Clin Pharmacol. 2017 Aug;83(8):1636-1642. doi: 10.1111/bcp.13280. Epub 2017 Apr 6.
- Results Sakpal TV. Sample size estimation in clinical trial. Perspect Clin Res. 2010 Apr;1(2):67-9.
- Results Lachin JM, Matts JP, Wei LJ. Randomization in clinical trials: conclusions and recommendations. Control Clin Trials. 1988 Dec;9(4):365-74. doi: 10.1016/0197-2456(88)90049-9.
- Results Berger VW, Bour LJ, Carter K, Chipman JJ, Everett CC, Heussen N, Hewitt C, Hilgers RD, Luo YA, Renteria J, Ryeznik Y, Sverdlov O, Uschner D; Randomization Innovative Design Scientific Working Group. A roadmap to using randomization in clinical trials. BMC Med Res Methodol. 2021 Aug 16;21(1):168. doi: 10.1186/s12874-021-01303-z.
- Results Pippi R. Post-Surgical Clinical Monitoring of Soft Tissue Wound Healing in Periodontal and Implant Surgery. Int J Med Sci. 2017 Jul 18;14(8):721-728. doi: 10.7150/ijms.19727. eCollection 2017.
- Results Zwahlen RA, Cheung LK, Zheng LW, Chow RL, Li T, Schuknecht B, Gratz KW, Weber FE. Comparison of two resorbable membrane systems in bone regeneration after removal of wisdom teeth: a randomized-controlled clinical pilot study. Clin Oral Implants Res. 2009 Oct;20(10):1084-91. doi: 10.1111/j.1600-0501.2009.01751.x.
- Results Covani U, Barone A, Cornelini R, Crespi R. Soft tissue healing around implants placed immediately after tooth extraction without incision: a clinical report. Int J Oral Maxillofac Implants. 2004 Jul-Aug;19(4):549-53.
- Results Gauer RL, Semidey MJ. Diagnosis and treatment of temporomandibular disorders. Am Fam Physician. 2015 Mar 15;91(6):378-86.
- Results Mamoun J. Dry Socket Etiology, Diagnosis, and Clinical Treatment Techniques. J Korean Assoc Oral Maxillofac Surg. 2018 Apr;44(2):52-58. doi: 10.5125/jkaoms.2018.44.2.52. Epub 2018 Apr 25.
- Results Keselman HJ, Algina J, Kowalchuk RK. The analysis of repeated measures designs: a review. Br J Math Stat Psychol. 2001 May;54(Pt 1):1-20. doi: 10.1348/000711001159357.
- Nejati Z, Ghadirzadeh B, Mohammadi H, Afraie M, Moradi Y. Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial. Pain Manag. 2025 Sep;15(9):555-569. doi: 10.1080/17581869.2025.2528590. Epub 2025 Jul 5.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Coenzyme Q10 | Other / unclassified | 100 mg | Oral |