drugset / Trial / NCT06452953
Modified Suanzaoren Decoction Versus Eszopiclone for the Treatment of Chronic Insomnia Disorder
Completed
85 enrolled
Central South University
The Third Hospital of Inner Mongolia Autonomous Region · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to observe the cognitive function and clinical efficacy of modified Suanzaoren decoction and eszopiclone in the treatment of chronic insomnia disorder patients, and to investigate the possible neural mechanisms using MRI techniques.
Timeline
- Start
- 2020-09-10
- Primary completion
- 2023-10-31
- Completion
- 2024-03-01
Publications
- Guo Z, Zhang L, Han Y, Yan H, Yao P, Lv D, Yuan Y, Zhao J, Chen L, Guo W. Altered Effective Connectivity of Precuneus Subregions and Associated Gene Profiles in Chronic Insomnia Disorder Patients Before and After Treatment. Brain Behav. 2026 May;16(5):e71448. doi: 10.1002/brb3.71448.
- Yao P, Guo X, Guo Z, Lin W, Liu M, Chen M, Li J, Cui LB, Lv D. Clinical efficacy of modified suanzaoren decoction compared to esazolam tablets in the treatment of chronic insomnia disorder. Front Psychiatry. 2025 Jul 24;16:1533652. doi: 10.3389/fpsyt.2025.1533652. eCollection 2025.
- Zhang L, Guo Z, Han Y, Yan H, Lv D, Yao P, Zhao J, Chen L, Guo W. Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment. World J Biol Psychiatry. 2025 Jun;26(5):211-223. doi: 10.1080/15622975.2025.2503938. Epub 2025 May 18.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Eszopiclone | Small molecule | 1 mg | — |
| Subject | Suanzaoren Decoction | Traditional medicine (herbal / TCM) | — | — |