Investigation of Endothelium-dependent Vasodilation in Human Gingiva

Summary

The first aim of this study is to create a cumulative dose-response curve for acetylcholine in men (low serum estrogen levels) to determine the lowest concentration with which we can induce a maximal vasodilation effect on the human gingiva. Furthermore, the second aim of this study is the characterization of the age-dependent effect of sex hormones on gingival blood flow, as well as of the gender differences by applying this concentration to premenopausal men and women with low and high estrogen levels, as well as to postmenopausal subjects.

Timeline

Start

2023-09-01

Primary completion

2024-12-31

Completion

2025-12-31

Drugs

Indications