Effects of Antiemetic Agents in Orthognathic Surgery Patients

Phase 4 Completed 66 enrolled Bezmialem Vakif University

RandomizedParallel-groupQuadruple-blindPrevention

Summary

In an effort to prevent or treat consistently high rates of PONV following maxillofacial operations, several medications, techniques and multimodal protocols have been studied. In the present study, the investigators hypothesized that combining metoclopramide with granisetron will improve PONV incidence when compared with granisetrone alone.

Timeline

Start: 2020-04-14
Primary completion: 2021-04-05
Completion: 2021-04-05

Outcome

Met primary endpoint

paper PONV scores at the second hour were 1.56 ± 1.45 in group G and 0.79 ± 0.90 in group GM (P = .03). PMID 39824505 ↗

paper Compared to granisetron alone, the combination of granisetron and metoclopramide was associated with significant PONV control PMID 39824505 ↗

Publications

Doganay Ozyilmaz O, Bayburt KA, Alkan A, Uysal H. Effects of Combined Antiemetic Protocol for the Prevention of Postoperative Nausea and Vomiting in Orthognathic Surgery: A Randomized Double Blinded Clinical Study. J Oral Maxillofac Surg. 2025 Apr;83(4):429-438. doi: 10.1016/j.joms.2024.12.010. Epub 2024 Dec 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Granisetron	Other / unclassified	3 mg	Intravenous
Subject	Intravenous drug	Unknown	10 mg	Intravenous