drugset / Trial / NCT06489951
Efficacy and Mechanism of High-Dose Vitamin D Supplementation in Pediatric OAB-Dry: A Randomized Clinical Trial Integrating Urinary Myelin Basic Protein as a Theranostic Biomarker
Completed
180 enrolled
Xing Liu
Beijing Children's Hospital · collabChildren's Hospital of Soochow University · collabGuizhou Provincial People's Hospital · collabShanghai Children's Hospital · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The aim of this study is to give children with dry OAB: (1) Standard behavioral therapy combined with classical anticholinergic drugs (Solinaxine), or (2) standard behavioral therapy combined with short-term high-dose exogenous vitamin D supplementation are used to compare the outcomes of lower urinary tract symptoms in children with dry OAB during follow-up. To provide more robust supporting evidence for the broader promotion of short-term high-dose exogenous vitamin D supplements in combination with standard behavioral therapy as an effective treatment for dry OAB treatment in children.
Timeline
- Start
- 2024-12-28
- Primary completion
- 2025-06-30
- Completion
- 2025-07-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Solifenacin | Small molecule | 0.5 mg | Oral |
| Subject | Solifenacin | Small molecule | 5 mg | Oral |