Efficacy and Safety of memanTine in the Treatment Of Frequently symPtomatic Atrial Premature Beats

Summary

A multicenter, randomized, double-blind, placebo-controlled study to expIore the efficacy and safety of Memantine hydrochIoride tabIets to treat patients with frequent PACs.

Timeline

Start

2024-08-29

Primary completion

2025-03-21

Completion

2025-05-16

Outcome

Met primary endpoint

paper memantine resulted in a greater reduction in PAC count than placebo (between-group difference, 47.1 percentage points; P=0.0045). PMID 41853846 ↗

Publications

• Shen Y, Zeng C, Sun Y, Wang J, Yu B, Cheng X, Guo X, Wang DW, Li Y, Han W, Zhou B, Sheng H, Huang Z, Li Y, Fu G, Zhang J, Xie D, Liang D, Liu Y, Yang B, Zhang Q, Duan R, Li H, Zhang B, Wu Y, Zheng L, He J, Liu S, Yin D, Sun G, Zhang S, Guo X, Zhang M, Wang Y, Hu X, Zeng J, Yang X, Li S, Li N, Hu F, Wang H, Hu X, Wang Y, Zeng C, Wang K, Yang J, Wang Y, Lai J, Wang L, Xiong K, Wang G, Zou Q, Shao B, Chen Z, Wu Y, Leng J, Pu J, Ma C, Chen YH. Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial. Circulation. 2026 Apr 21;153(16):1196-1209. doi: 10.1161/CIRCULATIONAHA.125.079023. Epub 2026 Mar 19.

Drugs

Indications