A Study to Evaluate Skin and Plasma Pharmacokinetic of Multiple Doses of Povorcitinib After Oral Administration in Healthy Participants

Phase 1 Completed 18 enrolled Incyte Corporation

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to measure the effect of multiple doses of orally administered povorcitinib on skin PK and to characterize plasma PK parameters of povorcitinib following multiple doses of orally administered povorcitinib.in healthy participants.

Timeline

Start: 2024-08-12
Primary completion: 2024-09-18
Completion: 2024-09-18

Publications

Xun Z, Zhang L, Wen H, McGee R, Wang P. Development and validation of a bioanalytical method to quantify povorcitinib in human skin with clinical application. Bioanalysis. 2025 Dec;17(24):1747-1758. doi: 10.1080/17576180.2025.2612493. Epub 2026 Jan 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Povorcitinib	Small molecule	—	Oral

Indications

No indication recorded.