First-in-Human Dose Escalation Study of XMT-1536 in Cancers Likely to Express NaPi2b

Summary

First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks. Patients with tumor types likely to express NaPi2b were enrolled in dose escalation. Patients with platinum-resistant ovarian cancer and non-small cell lung cancer (adenocarcinoma subtype) were enrolled in the expansion segment of this study. In addition to safety assessments, the pharmacokinetics of the drug were assessed along with ADC activity.

Timeline

Start

2017-12-12

Primary completion

2021-07-09

Completion

2021-07-09

Drugs

Indications