drugset / Trial / NCT06517485
First-in-Human Dose Expansion Study of XMT-1536 in Cancers Likely to Express NaPi2b
Non-randomizedParallel-groupOpen-labelTreatment
Summary
First-in-human, Phase 1b/2 safety study of the antibody-drug conjugate (ADC) XMT-1536 (upifitamab rilsodotin) administered as an intravenous infusion once every four weeks. Patients with platinum-resistant ovarian cancer and non-small cell lung cancer (adenocarcinoma subtype) were enrolled in the expansion segment of this study. In addition to safety assessments, the pharmacokinetics of the drug were assessed along with ADC activity.
Timeline
- Start
- 2019-07-30
- Primary completion
- 2022-05-31
- Completion
- 2022-08-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | upifitamab rilsodotin | Other / unclassified | — | Intravenous |