Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

Summary

Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects. The purpose of this study is to assess the feasibility, tolerability, and preliminary efficacy of psilocybin therapy for adults with chronic neuropathic pain and co-morbid treatment resistant depression.

Timeline

Start

2025-04-01

Primary completion

2027-03

Completion

2027-12

Drugs

Indications