drugset / Trial / NCT06543992
Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Leptomeningeal Metastasis
Phase 2
Recruiting
22 enrolled
The First Affiliated Hospital with Nanjing Medical University
The Affiliated Brain Hospital of Nanjing Medical University · collab
NaSingle-groupOpen-labelTreatment
Summary
Evaluate the efficacy and safety of Intrathecal Administration of Thiotepa in Combination with Methotrexate via the Ommaya Reservoir in Breast Cancer with Leptomeningeal Metastasis
Timeline
- Start
- 2024-07-13
- Primary completion
- 2026-12-13
- Completion
- 2026-12-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methotrexate | Small molecule | 15 mg | Intrathecal |
| Subject | Thiotepa | Other / unclassified | 10 mg | Intrathecal |