Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

Phase 3 Completed 150 enrolled Rose Research Center, LLC Global Action to End Smoking · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

To determine whether smokers who initially respond (within 2 weeks) to nicotine products (including nicotine replacement therapy, e-cigarettes, nicotine pouches) by reducing their smoking by ≥50% can be successfully maintained on use of these noncombustible nicotine alternatives to cigarettes for 6 months, and whether this results in sustained smoking reduction/abstinence.

Timeline

Start: 2024-08-29
Primary completion: 2025-12-09
Completion: 2025-12-09

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicorette 4Mg Chewing Gum	Unknown	4 mg	—
Subject	Nicotine	Unknown	4 mg	—
Subject	Nicotine	Unknown	—	—

Indications

No indication recorded.