Evaluation of Patients With Refractory Dermatomyositis Using [18F] FAPI-74 PET/MRI Imaging

Summary

This study proposes the use of a PET isotope, \[18F\]-Fibroblast Activation Protein Inhibitor-74, for a prospective single-center, single-arm study using MRI imaging for participants with Refractory Dermatomyostitis.

Timeline

Start

2024-12

Primary completion

2027-10

Completion

2028-10

Publications

• Background Bergmann C, Distler JHW, Treutlein C, Tascilar K, Muller AT, Atzinger A, Matei AE, Knitza J, Gyorfi AH, Luck A, Dees C, Soare A, Ramming A, Schonau V, Distler O, Prante O, Ritt P, Gotz TI, Kohner M, Cordes M, Bauerle T, Kuwert T, Schett G, Schmidkonz C. 68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre, pilot study. Lancet Rheumatol. 2021 Mar;3(3):e185-e194. doi: 10.1016/S2665-9913(20)30421-5. Epub 2021 Jan 25.
• Background Giesel FL, Adeberg S, Syed M, Lindner T, Jimenez-Franco LD, Mavriopoulou E, Staudinger F, Tonndorf-Martini E, Regnery S, Rieken S, El Shafie R, Rohrich M, Flechsig P, Kluge A, Altmann A, Debus J, Haberkorn U, Kratochwil C. FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients. J Nucl Med. 2021 Feb;62(2):201-207. doi: 10.2967/jnumed.120.245084. Epub 2020 Jun 26.
• Background Kuwert T, Schmidkonz C, Prante O, Schett G, Ramming A. FAPI PET Opens a New Window to Understanding Immune-Mediated Inflammatory Diseases. J Nucl Med. 2022 Aug;63(8):1136-1137. doi: 10.2967/jnumed.122.263922. Epub 2022 Apr 7. No abstract available.
• Background Li J, Wei W, Xu W, Wu W, Liu J, Ye S. [68Ga]Ga-FAPI-04 and [18F]FDG PET/ CT in a patient with MDA5 dermatomyositis. Eur J Nucl Med Mol Imaging. 2023 Oct;50(12):3790-3791. doi: 10.1007/s00259-023-06291-4. Epub 2023 Jun 5. No abstract available.
• Background Meyer C, Dahlbom M, Lindner T, Vauclin S, Mona C, Slavik R, Czernin J, Haberkorn U, Calais J. Radiation Dosimetry and Biodistribution of 68Ga-FAPI-46 PET Imaging in Cancer Patients. J Nucl Med. 2020 Aug;61(8):1171-1177. doi: 10.2967/jnumed.119.236786. Epub 2019 Dec 13.
• Background Treutlein C, Distler JHW, Tascilar K, Fakhouri SC, Gyorfi AH, Atzinger A, Matei AE, Dees C, Buttner-Herold M, Kuwert T, Prante O, Bauerle T, Uder M, Schett G, Schmidkonz C, Bergmann C. Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga-FAPI-04-PET-CT. Eur J Nucl Med Mol Imaging. 2023 May;50(6):1629-1635. doi: 10.1007/s00259-022-06081-4. Epub 2022 Dec 16.
• Background Wu J, Qiu L, Wang Y, Zhang C. Dermatomyositis on 68Ga-FAPI PET/CT in a Patient With Nasopharyngeal Carcinoma. Clin Nucl Med. 2022 Feb 1;47(2):149-150. doi: 10.1097/RLU.0000000000003809.
• Background Zheng J, Chen H, Lin K, Yao S, Miao W. [68Ga]Ga-FAPI and [18F]FDG PET/CT images in a patient with juvenile polymyositis. Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):2051-2052. doi: 10.1007/s00259-020-05185-z. Epub 2021 Jan 18. No abstract available.

Drugs

Indications