drugset / Trial / NCT06574763

Neoadjuvant RC48 Plus Carboplatin for HER2-expressing Advanced Ovarian Cancer

NCT06574763

Phase 2 Not yet recruiting 47 enrolled Sun Yat-sen University
NaSingle-groupOpen-labelTreatment

Summary

The goal of this phase II single arm prospective clinical study is to evaluate the efficacy and toxicity of RC48 plus carboplatin neoadjuvant therapy in HER2 expressed epithelial ovarian cancer patients. The main questions it aims to answer are: * The improvement of complete resection rate and pathological complete rate of this regimen. * The delayed effect of treatment regimens on patient's recurrence.

Timeline

Start
2024-09-01
Primary completion
2025-09-01
Completion
2026-09-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Carboplatin Small molecule 5 unknown Intravenous
Subject Disitamab Vedotin Other / unclassified 2.5 mg/kg Intravenous

Indications