drugset / Trial / NCT06606847

A Study to Investigate the Effects of Durvalumab With Oleclumab Following Chemoradiation in Participants With Locally Advanced Unresectable Non-Small Cell Lung Cancer (LADOGA)

NCT06606847

Phase 2 Active not recruiting 30 enrolled AstraZeneca
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this Phase II, open-label, multicentre, single-arm study is to assess efficacy and safety of durvalumab (MEDI4736) in combination with oleclumab (MEDI9447) in participants with locally advanced (Stage III), unresectable non-small cell lung cancer (NSCLC), who have not progressed following platinum-based concurrent or sequential chemoradiotherapy (cCRT or sCRT).

Timeline

Start
2024-09-24
Primary completion
2026-05-04
Completion
2027-03-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Durvalumab Monoclonal antibody Intravenous
Subject Oleclumab Monoclonal antibody Intravenous