Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve Surgery

Completed 142 enrolled Chinese PLA General Hospital Beijing Tiantan Hospital · collab Navy General Hospital, Beijing · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

A multicenter, randomized controlled, blinded prospective study to investigate the effects of esketamine on perioperative anxiety and depression in patients undergoing cardiac valve surgery.

Timeline

Start: 2024-09-23
Primary completion: 2025-04-07
Completion: 2025-04-30

Publications

Zhang ZN, Hao XY, Cai C, Sun L, Zhang ZY, Wang M, Wu YS, Wang Y, Cao JB, Liu YH, Lou JS, Fu Q, Jiang SL, Han RQ, Mi WD, Tong L. Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial. Pharmacol Res. 2025 Dec;222:108047. doi: 10.1016/j.phrs.2025.108047. Epub 2025 Nov 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esketamine	Other / unclassified	0.3 mg/kg	Intravenous

Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve Surgery

Summary

Timeline

Publications

Drugs

Indications