drugset / Trial / NCT06621004

Low Dose Magnesium Sulphate

NCT06621004

Phase 0 Enrolling by invitation 130 enrolled Ain Shams University
RandomizedParallel-groupTriple-blindSupportive care

Summary

This clinical trial aims to compare Patients who receive propranolol 1-2 mg to Patients who receive propranolol 1-2 mg in addition to magnesium sulphate infusion 10 mg/kg to see if IV magnesium can stability mean arterial blood pressure and heart rate in patients undergoing nasal surgeries as well as the quality of postoperative analgesia, degree of sedation mean arterial blood pressure and HR will be recorded intraoperative and Participants will be asked to rate the pain at the first, second, fourth, sixth and 24th postoperative hour using the VAS score. * Analgesic requirements: The time to first demand analgesia and the total amount of analgesia required in the 1st 24 will be recorded. * Sedation score: the degree of sedation will be assessed using the Ramsy sedation score

Timeline

Start
2024-08-25
Primary completion
2024-12-31
Completion
2025-01-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Magnesium Sulfate Other / unclassified 10 mg/kg Intravenous
Comparator Propranolol Small molecule 1 mg
Comparator Propranolol Small molecule 2 mg

Indications

No indication recorded.