drugset / Trial / NCT06629337

Effect of Aerobic Exercise with Blood Flow Restriction on Post-exercise Hypotension in Young Adults: the Role of Histamine Receptors

NCT06629337

Completed 10 enrolled California Baptist University
RandomizedCrossoverOpen-labelBasic science

Summary

It was hypothesized that aerobic exercise with blood flow restriction (BFR) induced post exercise hypotension (PEH), and the reduction in blood pressure (BP) was due to peripheral vasodilation via the histamine receptors. Ten male participants participated in this study. The participants were randomly assigned to walk for 10 minutes at 6.4 k/m, 0% grade with or without BFR after taking histamine receptor blockade. Following exercise, BP was measured at 10 min interval for 60 minutes. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure (MAP), and total peripheral resistance (TPR) were evaluated.

Timeline

Start
2024-04-01
Primary completion
2024-08-31
Completion
2024-08-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Famotidine Other / unclassified 40 mg Oral
Subject Fexofenadine Unknown 540 mg Oral

Indications