drugset / Trial / NCT06630884
Inflammatory Challenge and Fear
Phase 1
Recruiting
288 enrolled
University of California, San Francisco
National Institute of Mental Health (NIMH) · collabNorthern California Institute of Research and Education · collabSan Francisco Veterans Affairs Medical Center · collab
RandomizedParallel-groupQuadruple-blindBasic science
Summary
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.
Timeline
- Start
- 2025-03-28
- Primary completion
- 2028-11
- Completion
- 2028-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Typhim Vi | Vaccine | 25 ug | Other |
| Subject | Typhim Vi | Vaccine | 0.5 ml | Other |