Effects of Substance P on Headache Induction in Healthy Individuals

NCT06632080 ↗

Not yet recruiting 21 enrolled Danish Headache Center

RandomizedCrossoverQuadruple-blindBasic science

Summary

Substance P is a signaling molecule that has been implicated in the pathogenesis of headache. This study aims to ascertain whether administration of substance P can induce headache in healthy adults.

Timeline

Start: 2024-10-14
Primary completion: 2025-12-31
Completion: 2025-12-31

Outcome

Met primary endpoint

paper Headache was reported by 15 (71%) of 21 participants following substance P, compared with two (10%) after placebo (p < 0.001). PMID 40369974 ↗

Publications

Al-Khazali HM, Christensen RH, Gozalov E, Hakimzadeh Z, Melchior AG, Dominguez-Moreno R, Ashina M, Ashina H. Effects of substance P on headache induction and arterial dilation in healthy adults. Cephalalgia. 2025 May;45(5):3331024251336132. doi: 10.1177/03331024251336132. Epub 2025 May 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Substance P	Small molecule	1.5 unknown	Intravenous

Indications

No indication recorded.