Opioid Use of Local Anaesthetic Agents in Open Heart Surgery and Its Effect on Recovery

Summary

The aim of this randomized controlled study was to investigate the effect of injecting local anesthetic agents into the sternotomy incision site and around the drains on the amount of opioids used in the postoperative period and the healing process. The main questions it aims to answer are: * In patients undergoing open heart surgery, does the application of local anesthetic around the sternotomy incision site and chest tube(s) reduce the amount of postoperative opioid use? * In patients undergoing open heart surgery, does the application of local anesthetic around the sternotomy incision site and chest tube(s) accelerate postoperative recovery? In this study, LIDOFAST 40 mg/2 ml + 0.025 mg/2 ml will be injected into the sternotomy incision area and around the drains of the patients in the experimental group, and the amount of opioid consumed in the postoperative period will be recorded and the healing process will be observed.

Timeline

Start

2023-08-01

Primary completion

2024-01-15

Completion

2024-03-15

Publications

• Results Ebrahimi S, Paryad E, Ghanbari Khanghah A, Pasdaran A, Kazemnezhad Leili E, Sadeghi Meibodi AM. The effects of lavandula aromatherapy on pain relief after coronary artery bypass graft surgery: A randomized clinical trial. Appl Nurs Res. 2022 Dec;68:151638. doi: 10.1016/j.apnr.2022.151638. Epub 2022 Oct 28.
• Results Choiniere M, Watt-Watson J, Victor JC, Baskett RJ, Bussieres JS, Carrier M, Cogan J, Costello J, Feindel C, Guertin MC, Racine M, Taillefer MC. Prevalence of and risk factors for persistent postoperative nonanginal pain after cardiac surgery: a 2-year prospective multicentre study. CMAJ. 2014 Apr 15;186(7):E213-23. doi: 10.1503/cmaj.131012. Epub 2014 Feb 24.
• Results Cogan J. Pain management after cardiac surgery. Semin Cardiothorac Vasc Anesth. 2010 Sep;14(3):201-4. doi: 10.1177/1089253210378401.
• Results White PF, Rawal S, Latham P, Markowitz S, Issioui T, Chi L, Dellaria S, Shi C, Morse L, Ing C. Use of a continuous local anesthetic infusion for pain management after median sternotomy. Anesthesiology. 2003 Oct;99(4):918-23. doi: 10.1097/00000542-200310000-00026.
• Results Dowling R, Thielmeier K, Ghaly A, Barber D, Boice T, Dine A. Improved pain control after cardiac surgery: results of a randomized, double-blind, clinical trial. J Thorac Cardiovasc Surg. 2003 Nov;126(5):1271-8. doi: 10.1016/s0022-5223(03)00585-3.
• Results Golembiewski J. Local anesthetics. J Perianesth Nurs. 2013 Dec;28(6):409-12. doi: 10.1016/j.jopan.2013.09.001. No abstract available.
• Results Shah J, Votta-Velis EG, Borgeat A. New local anesthetics. Best Pract Res Clin Anaesthesiol. 2018 Jun;32(2):179-185. doi: 10.1016/j.bpa.2018.06.010. Epub 2018 Jul 3.
• Results Jannati M, Attar A. Analgesia and sedation post-coronary artery bypass graft surgery: a review of the literature. Ther Clin Risk Manag. 2019 Jun 20;15:773-781. doi: 10.2147/TCRM.S195267. eCollection 2019.
• Results Brown CR, Chen Z, Khurshan F, Groeneveld PW, Desai ND. Development of Persistent Opioid Use After Cardiac Surgery. JAMA Cardiol. 2020 Aug 1;5(8):889-896. doi: 10.1001/jamacardio.2020.1445.
• Results Reisli R, Akkaya OT, Arican S, Can OS, Cetingok H, Gulec MS, Koknel Talu G. [Pharmachologic treatment of acute postoperative pain: A clinical practice guideline of The Turkish Society of Algology]. Agri. 2021 Jan;33(Suppl 1):1-51. doi: 10.14744/agri.2021.60243. Turkish.
• Azizoglu H, Asam M, Gurkan Z, Bozkurt Y, Demir C. The effect of local anaesthetic agents on opioid use and recovery in patients undergoing open heart surgery: a randomized controlled study. BMC Cardiovasc Disord. 2025 Feb 1;25(1):72. doi: 10.1186/s12872-025-04493-2.

Drugs

Indications

No indication recorded.