drugset / Trial / NCT06649851

G-CSF After Chemo-radiation in Patients With Glioblastoma

NCT06649851

Phase 2 Recruiting 60 enrolled Massachusetts General Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

This research study involves the study of granulocyte colony stimulating factor (G-CSF) in patients with MGMT-methylated glioblastoma multiforme (GBM) that are undergoing standard chemoradiation. The study aims to evaluate G-CSF's effects on brain health and cognitive function. The name of the study drugs involved in this study are: * G-CSF (also called Filgrastim) * Temozolomide (TMZ), a standard of care chemotherapy drug

Timeline

Start
2025-04-02
Primary completion
2027-01-31
Completion
2030-01-31

Drugs

EvaluationDrugModalityDoseRoute
Subject filgrastim Protein / enzyme biologic 5 ug/kg Subcutaneous
Subject filgrastim Protein / enzyme biologic 7 ug/kg Subcutaneous

Indications