Levofloxacin Plus Metronidazole Suppositories Versus Levofloxacin Co-administered with Metronidazole Tablets in Chronic Endometritis

Not yet recruiting 800 enrolled Peking University Third Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

This is a single randomised controlled trial. The investigators plan to randomise 800 participants to the levofloxacin plus metronidazole suppositories versus levofloxacin co-administered with metronidazole tablets for the treatment of chronic endometritis in a 1:1 rate. Primary outcome will be the live birth rate after the embryo transfer.

Timeline

Start: 2024-10-22
Primary completion: 2025-10-22
Completion: 2026-12-30

Publications

Lin M, Wang Y, Lv X, Lin Z, Zeng Z, Mo D, Shan H, Li R. Administration of levofloxacin combined with metronidazole suppositories prior to in vitro fertilisation in women with chronic endometritis: a protocol of a single-centre, randomised, controlled clinical trial. BMJ Open. 2025 Sep 15;15(9):e098500. doi: 10.1136/bmjopen-2024-098500.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levofloxacin	Small molecule	—	Oral
Subject	Metronidazole	Small molecule	—	Oral

Indications

No indication recorded.