The Efficacy and Safety of Diluted Oral Phosphate Enema Versus Intravenous Sodium Glycerophosphate in The Treatment of Hypophosphatemia in ICU Patients

Summary

The goal of this clinical trial is to study the efficacy and safety of diluted phosphate enema in treating hypophosphatemia in adults in critical care unit in comparison to intravenous sodium glycero-phosphate as the current standard of care. The main question it aims to answer is: can the investigators rely on phosphate enemas as an effective and safe treatment option for hypophosphatemia in critically ill adults, in the era of global shortage of parenteral nutrition solutions and the absence of defined guidelines for treatment of acute hypophosphatemia in those population.

Timeline

Start

2024-05-01

Primary completion

2024-12-30

Completion

2024-12-30

Outcome

Met primary endpoint

paper CONCLUSION: The oral administration of phosphate enema was found non-inferior to the IV administration of sodium glycerophosphate in treating mild to moderate hypophosphatemia in ICU patients. PMID 41242387 ↗

Publications

• Najdi H, Sayed R, Mettawi AS, El-Hamamsy M. The efficacy and safety of diluted oral phosphate enema versus intravenous sodium glycerophosphate in the treatment of hypophosphatemia in intensive care unit patients - A non-inferiority trial. Clin Nutr ESPEN. 2025 Dec;70:692-700. doi: 10.1016/j.clnesp.2025.11.015. Epub 2025 Nov 14.

Drugs

Indications