To Evaluate the Safety and Efficacy of TD0015 Pilulae in Patients with Knee Osteoarthritis

Summary

Preclinical trials in animal models have suggested that the estimated dose of TD0015 in clinical presents no safety concerns.The investigational product is TD0015 pilulae, which is based on the traditional prescription named "Độc hoạt tang ký sinh thang" (Thien Kim Phuong). The traditional prescription has the effect of circulating blood in the tendons and bones to bring out evil spirits, blood tonic, kidney tonic to prevent recurrence of diseases and against joint degeneration, joint deformation, muscle atrophy, stiffness to recover normal joint function.

Timeline

Start

2021-07-01

Primary completion

2024-11

Completion

2024-11

Publications

• Ha NTT, Nghia DT, Nga HTV, Lua TT, Hong NTB, Hanh NT, Ngoc NK, Vuong NL. Traditional Vietnamese herbal medicine TD0015 in Knee Osteoarthritis: A Phase-II randomized controlled trial. Integr Med Res. 2025 Jun;14(2):101143. doi: 10.1016/j.imr.2025.101143. Epub 2025 Mar 31.

Drugs

Indications