drugset / Trial / NCT06660654

A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)

NCT06660654

Phase 2 Active not recruiting 200 enrolled Daiichi Sankyo Merck Sharp & Dohme LLC · collab
Non-randomizedSingle-groupOpen-labelTreatment

Summary

This pan-tumor trial is designed as a signal-seeking trial to assess efficacy and safety of raludotatug deruxtecan (R-DXd) monotherapy in locally advanced or metastatic solid tumors with various cadherin-6 (CDH6) expression levels, including gynecological cancers (endometrial cancer, cervical cancer, and non-high-grade serous ovarian cancer) and genitourinary cancers (urothelial cancer and clear cell renal cell carcinoma \[ccRCC\]).

Timeline

Start
2025-01-06
Primary completion
2027-09-30
Completion
2027-09-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Raludotatug Deruxtecan Other / unclassified Intravenous

Indications