drugset / Trial / NCT06671405
An Open-label Study in Healthy Participants to Evaluate AZD0780 as an Object or Precipitant of CYP3A4-mediated Drug-drug Interactions
Non-randomizedSequentialOpen-labelOther
Summary
An open-label, fixed sequence study in healthy participants to assess the pharmacokinetics of AZD0780 when administered alone and in combination with itraconazole and carbamazepine, and to assess the pharmacokinetics of midazolam and ethinyl estradiol/levonorgestrel (EE and LNG) when administered alone and in combination with AZD0780.
Timeline
- Start
- 2024-09-25
- Primary completion
- 2025-02-17
- Completion
- 2025-02-17
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carbamazepine | Small molecule | 100 mg | — |
| Subject | Carbamazepine | Small molecule | 200 mg | — |
| Subject | Carbamazepine | Small molecule | 300 mg | — |
| Subject | Itraconazole | Small molecule | — | — |
| Subject | Laroprovstat | Small molecule | — | — |
| Subject | Levonorgestrel | Small molecule | — | — |
| Subject | Midazolam | Small molecule | — | — |
| Subject | ethinyl estradiol | Small molecule | — | — |