drugset / Trial / NCT06686394

Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

NCT06686394

Phase 1/2 Recruiting 81 enrolled Merck Sharp & Dohme LLC Daiichi Sankyo · collab
Non-randomizedSequentialOpen-labelTreatment

Summary

Researchers want to learn if patritumab deruxtecan (MK-1022) can treat certain breast cancers. The breast cancers being studied are HER2 positive unresectable locally advanced or metastatic (the cancer has spread to other parts of the body). The goals of this study are to learn: * About the safety and how well people tolerate of patritumab deruxtecan * How many people have the cancer respond (get smaller or go away) to treatment

Timeline

Start
2025-02-26
Primary completion
2030-04-18
Completion
2030-04-18

Drugs

EvaluationDrugModalityDoseRoute
Subject Patritumab deruxtecan Monoclonal antibody Intravenous
Subject Pertuzumab Monoclonal antibody Intravenous
Subject Trastuzumab Monoclonal antibody Intravenous
Subject Tucatinib Small molecule Oral

Indications