drugset / Trial / NCT06687551
JAK Inhibitor Dose TAPering Strategy Study
RandomizedParallel-groupSingle-blindTreatment
Summary
This study aims to assess the feasibility of tapering JAK inhibitors in rheumatoid arthritis patients in low disease activity by comparing a group of patients tapering the JAK inhibitor dosage to a group of patients continuing the full-dose. Participants will: * Either take 1. JAK inhibitor dose-tapering strategy. 2. JAK inhibitor continuous therapy strategy. * Visit the clinic once every 3 months for checkups and tests * Keep a diary of their treatment intake and symptoms
Timeline
- Start
- 2025-01-01
- Primary completion
- 2029-04-01
- Completion
- 2029-04-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Baricitinib | Small molecule | 2 mg | — |
| Comparator | Baricitinib | Small molecule | 4 mg | — |
| Comparator | Filgotinib | Small molecule | 100 mg | — |
| Comparator | Filgotinib | Small molecule | 200 mg | — |
| Comparator | Tofacitinib | Small molecule | 5 mg | — |
| Comparator | Tofacitinib | Small molecule | 11 mg | — |
| Comparator | Upadacitinib | Small molecule | 15 mg | — |