drugset / Trial / NCT06691191
Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors
RandomizedParallel-groupOpen-labelTreatment
Summary
Ticagrelor currently represents the most tested and commonly used P2Y12 inhibitor monotherapy following percutaneous coronary intervention. The purpose of this study is to conduct a head-to-head comparison on the pharmacodynamic efficacy of ticagrelor-based and prasugrel-based single antiplatelet therapy. To determine if the PD profiles of ticagrelor- and prasugrel-based SAPT are comparable, we aim to conduct a non-inferiority study between the two strategies.
Timeline
- Start
- 2025-01-08
- Primary completion
- 2026-08-31
- Completion
- 2026-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Prasugrel | Small molecule | 10 mg | — |
| Comparator | Ticagrelor | Small molecule | 90 mg | — |