drugset / Trial / NCT06691191

Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors

NCT06691191

Phase 4 Recruiting 48 enrolled University of Florida
RandomizedParallel-groupOpen-labelTreatment

Summary

Ticagrelor currently represents the most tested and commonly used P2Y12 inhibitor monotherapy following percutaneous coronary intervention. The purpose of this study is to conduct a head-to-head comparison on the pharmacodynamic efficacy of ticagrelor-based and prasugrel-based single antiplatelet therapy. To determine if the PD profiles of ticagrelor- and prasugrel-based SAPT are comparable, we aim to conduct a non-inferiority study between the two strategies.

Timeline

Start
2025-01-08
Primary completion
2026-08-31
Completion
2026-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Prasugrel Small molecule 10 mg
Comparator Ticagrelor Small molecule 90 mg