drugset / Trial / NCT06707181

Comparative Study for Medical Therapy for Lower Ureteral Stones

NCT06707181

Phase 3 Completed 180 enrolled Beni-Suef University
RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to compare the efficacy and adverse effects of different drugs as a medical expulsive therapy for lower ureteral stones. The main questions it aims to answer are: * Which of the following are more effective silodosin, tamsulosin, silodosin plus tadalafil and tamsulosin plus tadalafil as a therapy for lower ureteral stones? * What medical problems do participants have when taking these drugs? Researchers will compare silodosin, tamsulosin, silodosin plus tadalafil and tamsulosin plus tadalafil to see which drug works better to treat lower ureteral stones Participants will: * Take silodosin, tamsulosin, silodosin plus tadalafil or tamsulosin plus tadalafil every day for 28 days * Visit the clinic once every 2 weeks for checkups and tests * Keep a diary of their symptoms.

Timeline

Start
2023-11-01
Primary completion
2024-05-20
Completion
2024-08-18

Drugs

EvaluationDrugModalityDoseRoute
Comparator Silodosin Unknown 8 mg
Subject Tadalafil Small molecule 5 mg
Comparator Tamsulosin Other / unclassified 0.4 mg

Indications